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Ipamorelin and sermorelin are two peptides often combined in hormone replacement or anti-aging protocols, each serving distinct yet complementary roles. Ipamorelin is a selective growth hormone secretagogue that stimulates the release of growth hormone (GH) by mimicking ghrelin activity at the pituitary level, while sermorelin is an analogue of growth hormone releasing hormone (GHRH) that triggers GH secretion through a different receptor pathway. Together they create a synergistic effect, increasing circulating levels of GH and insulin-like growth factor www.valley.md 1 (IGF-1) more effectively than either agent alone.